Selective depletion of microglial progranulin in mice is not sufficient to cause neuronal ceroid lipofuscinosis or neuroinflammation

Abstract Background Progranulin deficiency due to heterozygous null mutations in the GRN gene are a common cause of familial frontotemporal lobar degeneration (FTLD), while homozygous loss-of-function GRN mutations are thought to be a rare cause of neuronal ceroid lipofuscinosis (NCL). Aged progranu...

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Egile Nagusiak:	Terri L. Petkau, Natalia Kosior, Kathleen de Asis, Colúm Connolly, Blair R. Leavitt
Formatua:	Artigo
Hizkuntza:	Inglês
Argitaratua:	BMC 2017-11-01
Saila:	Journal of Neuroinflammation
Gaiak:	Frontotemporal lobar degeneration Neuronal ceroid lipofuscinosis Progranulin Conditional knockout mice Neuropathology Lysozyme promotor
Sarrera elektronikoa:	http://link.springer.com/article/10.1186/s12974-017-1000-9
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