α-Synuclein-mediated neurodegeneration in Dementia with Lewy bodies: the pathobiology of a paradox

Abstract Dementia with Lewy bodies (DLB) is epitomized by the pathognomonic manifestation of α-synuclein-laden Lewy bodies within selectively vulnerable neurons in the brain. By virtue of prion-like inheritance, the α-synuclein protein inexorably undergoes extensive conformational metamorphoses and...

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Номзүйн дэлгэрэнгүй

Үндсэн зохиолчид:	Christopher Simon, Tomoko Soga, Hirotaka James Okano, Ishwar Parhar
Формат:	Artigo
Хэл сонгох:	Inglês
Хэвлэсэн:	BMC 2021-11-01
Цуврал:	Cell & Bioscience
Нөхцлүүд:	Alzheimer’s disease Parkinson’s disease Braak hypothesis Oligomers Fibrils
Онлайн хандалт:	https://doi.org/10.1186/s13578-021-00709-y
Шошгууд:	Шошго нэмэх Шошго байхгүй, Энэхүү баримтыг шошголох эхний хүн болох!