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Discrepancy between distribution of alpha-synuclein oligomers and Lewy-related pathology in Parkinson’s disease

Abstract The pathological hallmarks of Parkinson’s disease (PD) are α-synuclein (αSYN)-positive inclusions referred to as Lewy bodies and Lewy neurites, collectively referred to as Lewy-related pathology (LRP). LRP is thought to propagate in an ascending manner throughout the brain as the disease pr...

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Principais autores: Hiroaki Sekiya, Asato Tsuji, Yuki Hashimoto, Mariko Takata, Shunsuke Koga, Katsuya Nishida, Naonobu Futamura, Michi Kawamoto, Nobuo Kohara, Dennis W. Dickson, Hisatomo Kowa, Tatsushi Toda
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2022-09-01
coleção:Acta Neuropathologica Communications
Assuntos:
Alpha-synuclein
Oligomers
Lewy bodies
Parkinson disease
Pathogenesis
Acesso em linha:https://doi.org/10.1186/s40478-022-01440-6
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