Transcriptomic Regulation of Muscle Mitochondria and Calcium Signaling by Insulin/IGF-1 Receptors Depends on FoxO Transcription Factors

Insulin and IGF-1, acting through the insulin receptor (IR) and IGF-1 receptor (IGF1R), maintain muscle mass and mitochondrial function, at least part of which occurs via their action to regulate gene expression. Here, we show that while muscle-specific deletion of IR or IGF1R individually results i...

詳細記述

書誌詳細

主要な著者:	Gourav Bhardwaj, Christie M. Penniman, Katherine Klaus, Eric T. Weatherford, Hui Pan, Jonathan M. Dreyfuss, K. Sreekumaran Nair, C. Ronald Kahn, Brian T. O’Neill
フォーマット:	Artigo
言語:	Inglês
出版事項:	Frontiers Media S.A. 2022-02-01
シリーズ:	Frontiers in Physiology
主題:	insulin/IGF-1 receptors FoxO transcription factors muscle transcription diabetes RNA sequencing mitochondrial dysfunction
オンライン･アクセス:	https://www.frontiersin.org/articles/10.3389/fphys.2021.779121/full
タグ:	タグ追加 タグなし, このレコードへの初めてのタグを付けませんか!