Transcriptomic Regulation of Muscle Mitochondria and Calcium Signaling by Insulin/IGF-1 Receptors Depends on FoxO Transcription Factors

Insulin and IGF-1, acting through the insulin receptor (IR) and IGF-1 receptor (IGF1R), maintain muscle mass and mitochondrial function, at least part of which occurs via their action to regulate gene expression. Here, we show that while muscle-specific deletion of IR or IGF1R individually results i...

תיאור מלא

מידע ביבליוגרפי

Principais autores:	Gourav Bhardwaj, Christie M. Penniman, Katherine Klaus, Eric T. Weatherford, Hui Pan, Jonathan M. Dreyfuss, K. Sreekumaran Nair, C. Ronald Kahn, Brian T. O’Neill
פורמט:	Artigo
שפה:	Inglês
יצא לאור:	Frontiers Media S.A. 2022-02-01
סדרה:	Frontiers in Physiology
נושאים:	insulin/IGF-1 receptors FoxO transcription factors muscle transcription diabetes RNA sequencing mitochondrial dysfunction
גישה מקוונת:	https://www.frontiersin.org/articles/10.3389/fphys.2021.779121/full
תגים:	הוספת תג אין תגיות, היה/י הראשונ/ה לתייג את הרשומה!