Transcriptomic Regulation of Muscle Mitochondria and Calcium Signaling by Insulin/IGF-1 Receptors Depends on FoxO Transcription Factors

Insulin and IGF-1, acting through the insulin receptor (IR) and IGF-1 receptor (IGF1R), maintain muscle mass and mitochondrial function, at least part of which occurs via their action to regulate gene expression. Here, we show that while muscle-specific deletion of IR or IGF1R individually results i...

ver descrição completa

Detalhes bibliográficos

Principais autores:	Gourav Bhardwaj, Christie M. Penniman, Katherine Klaus, Eric T. Weatherford, Hui Pan, Jonathan M. Dreyfuss, K. Sreekumaran Nair, C. Ronald Kahn, Brian T. O’Neill
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2022-02-01
coleção:	Frontiers in Physiology
Assuntos:	insulin/IGF-1 receptors FoxO transcription factors muscle transcription diabetes RNA sequencing mitochondrial dysfunction
Acesso em linha:	https://www.frontiersin.org/articles/10.3389/fphys.2021.779121/full
Tags:	Adicionar Tag Sem tags, seja o primeiro a adicionar uma tag!