Voluntary running reduces loss of PTEN-deficient Purkinje cells, modulates their metabolic signaling, and improves motor deficits in mice

Dysregulation of the PTEN-mTORC1 signaling pathway disrupts cellular metabolism and contributes to neurodevelopmental disorders, including autism spectrum disorder (ASD). In cerebellar Purkinje cells (PCs), PTEN deficiency leads to hyperactivation of mTORC1, impaired energy homeostasis, and progress...

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Principais autores:	Siena R. Brazier, Kathryn L. Ditrano, David S. Betancourt-Trompa, Grace A. Belt, Olivia R. Barbarini, Ursula M. Pena, Izabella M. Espinal-San Miguel, Ana V. Rodriguez, Carly N. Immerman, Cameron J. Petrelli, Reagan R. Dennett, Rohan Reddy, Daniel J. Greenspan, Lindsay J. Walsh, Connor Enestvedt, Campbell M. Bridges, Pamela A. Snodgrass-Belt, Ileana Soto
פורמט:	Artigo
שפה:	Inglês
יצא לאור:	Frontiers Media S.A. 2026-07-01
סדרה:	Frontiers in Cellular Neuroscience
נושאים:	AMPK cerebellum microglia mTORC1 Pten
גישה מקוונת:	https://www.frontiersin.org/articles/10.3389/fncel.2026.1865302/full
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