Voluntary running reduces loss of PTEN-deficient Purkinje cells, modulates their metabolic signaling, and improves motor deficits in mice

Dysregulation of the PTEN-mTORC1 signaling pathway disrupts cellular metabolism and contributes to neurodevelopmental disorders, including autism spectrum disorder (ASD). In cerebellar Purkinje cells (PCs), PTEN deficiency leads to hyperactivation of mTORC1, impaired energy homeostasis, and progress...

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Bibliografiske detaljer

Principais autores:	Siena R. Brazier, Kathryn L. Ditrano, David S. Betancourt-Trompa, Grace A. Belt, Olivia R. Barbarini, Ursula M. Pena, Izabella M. Espinal-San Miguel, Ana V. Rodriguez, Carly N. Immerman, Cameron J. Petrelli, Reagan R. Dennett, Rohan Reddy, Daniel J. Greenspan, Lindsay J. Walsh, Connor Enestvedt, Campbell M. Bridges, Pamela A. Snodgrass-Belt, Ileana Soto
Format:	Artigo
Sprog:	Inglês
Udgivet:	Frontiers Media S.A. 2026-07-01
Serier:	Frontiers in Cellular Neuroscience
Fag:	AMPK cerebellum microglia mTORC1 Pten
Online adgang:	https://www.frontiersin.org/articles/10.3389/fncel.2026.1865302/full
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