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Reversing Persistent PTEN Activation after Traumatic Brain Injury Fuels Long‐Term Axonal Regeneration via Akt/mTORC1 Signaling Cascade

Abstract Traumatic brain injury (TBI) often leads to enduring axonal damage and persistent neurological deficits. While PTEN's role in neuronal growth is recognized, its long‐term activation changes post‐TBI and its effects on sensory‐motor circuits are not well understood. Here, it is demonstrated...

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Hlavní autoři: Ziyu Shi, Leilei Mao, Shuning Chen, Zhuoying Du, Jiakun Xiang, Minghong Shi, Yana Wang, Yuqing Wang, Xingdong Chen, Zhi‐Xiang Xu, Yanqin Gao
Médium: Artigo
Jazyk:Inglês
Vydáno: Wiley 2025-02-01
Edice:Advanced Science
Témata:
axon regeneration
cortical remapping
mTORC1
PTEN
TBI
On-line přístup:https://doi.org/10.1002/advs.202410136
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