Codice QR

Allosteric modulation and direct activation of glycine receptors by a tricyclic sulfonamide

Abstract Ionotropic glycine receptors (GlyRs) are chloride-permeable ligand-gated ion channels expressed in the nervous system. Alterations to glycinergic inhibition and the generation of dysfunctional GlyRs have been linked to chronic pain, a widely prevalent disease. Positive allosteric modulators...

Descrizione completa

Salvato in:
Autori principali: César O. Lara, Carlos F. Burgos, Katherine Fariña-Oliva, Ana M. Marileo, Victoria P. San Martín, David Flaig, Paul Soto-Ortega, Omayra V. Contreras, Anggelo Sazo, Krishna Gaete-Riquelme, Jeremías Corradi, Carola Muñoz-Montesino, Jorge Fuentealba, Patricio A. Castro, Luis G. Aguayo, Cecilia Bouzat, Gustavo Moraga-Cid, Gonzalo E. Yévenes
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Portfolio 2025-02-01
Serie:Scientific Reports
Soggetti:
Glycine receptors
Allosteric modulation
Electrophysiology
Molecular modelling
Pharmacology
Chronic pain
Accesso online:https://doi.org/10.1038/s41598-025-90209-7
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne!!

Documenti analoghi