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Determination of the Cannabinoid CB1 Receptor’s Positive Allosteric Modulator Binding Site through Mutagenesis Studies

Positive allosteric modulators (PAMs) of the cannabinoid CB1 receptor (CB<sub>1</sub>) offer potential therapeutic advantages in the treatment of neuropathic pain and addiction by avoiding the adverse effects associated with orthosteric CB<sub>1</sub> activation. Here, molecular modeling and mutagen...

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Autors principals: Hayley M. Green, Daniel M. J. Fellner, David B. Finlay, Daniel P. Furkert, Michelle Glass
Format: Artigo
Idioma:Inglês
Publicat: MDPI AG 2024-01-01
Col·lecció:Pharmaceuticals
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Accés en línia:https://www.mdpi.com/1424-8247/17/2/154
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