Neutralizing antibody 5-7 defines a distinct site of vulnerability in SARS-CoV-2 spike N-terminal domain

Summary: Antibodies that potently neutralize SARS-CoV-2 target mainly the receptor-binding domain or the N-terminal domain (NTD). Over a dozen potently neutralizing NTD-directed antibodies have been studied structurally, and all target a single antigenic supersite in NTD (site 1). Here, we report th...

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Detalhes bibliográficos

Principais autores:	Gabriele Cerutti, Yicheng Guo, Pengfei Wang, Manoj S. Nair, Maple Wang, Yaoxing Huang, Jian Yu, Lihong Liu, Phinikoula S. Katsamba, Fabiana Bahna, Eswar R. Reddem, Peter D. Kwong, David D. Ho, Zizhang Sheng, Lawrence Shapiro
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2021-11-01
coleção:	Cell Reports
Assuntos:	COVID-19 cryo-EM neutralizing antibody N-terminal domain NTD antigenic supersite
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S2211124721014017
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