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Neutralizing antibody 5-7 defines a distinct site of vulnerability in SARS-CoV-2 spike N-terminal domain

Summary: Antibodies that potently neutralize SARS-CoV-2 target mainly the receptor-binding domain or the N-terminal domain (NTD). Over a dozen potently neutralizing NTD-directed antibodies have been studied structurally, and all target a single antigenic supersite in NTD (site 1). Here, we report th...

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Principais autores: Gabriele Cerutti, Yicheng Guo, Pengfei Wang, Manoj S. Nair, Maple Wang, Yaoxing Huang, Jian Yu, Lihong Liu, Phinikoula S. Katsamba, Fabiana Bahna, Eswar R. Reddem, Peter D. Kwong, David D. Ho, Zizhang Sheng, Lawrence Shapiro
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2021-11-01
Serier:Cell Reports
Fag:
COVID-19
cryo-EM
neutralizing antibody
N-terminal domain
NTD
antigenic supersite
Online adgang:http://www.sciencedirect.com/science/article/pii/S2211124721014017
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