Doxycycline-dependent Cas9-expressing pig resources for conditional in vivo gene nullification and activation

Abstract Background CRISPR-based toolkits have dramatically increased the ease of genome and epigenome editing. SpCas9 is the most widely used nuclease. However, the difficulty of delivering SpCas9 and inability to modulate its expression in vivo hinder its widespread adoption in large animals. Resu...

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Bibliografiske detaljer

Principais autores:	Qin Jin, Xiaoyi Liu, Zhenpeng Zhuang, Jiayuan Huang, Shixue Gou, Hui Shi, Yu Zhao, Zhen Ouyang, Zhaoming Liu, Lei Li, Junjie Mao, Weikai Ge, Fangbing Chen, Manya Yu, Yezhi Guan, Yinghua Ye, Chengcheng Tang, Ren Huang, Kepin Wang, Liangxue Lai
Format:	Artigo
Sprog:	Inglês
Udgivet:	BMC 2023-01-01
Serier:	Genome Biology
Online adgang:	https://doi.org/10.1186/s13059-023-02851-x
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