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A multifaceted approach for the development of novel Hantzsch 1,4-dihydropyridines as anticancer agents: Rational design, parallel synthesis, analysis, cytotoxicity and EGFR/HER2 inhibition studies

Dihydropyridines (DHPs) exhibit a wide range of pharmacological properties especially against cancer. In this context, a new series of 1,4-dihydropyridines were meticulously designed employing scaffold hybridization technique targeting the EGFR/HER2 receptors. The parallel synthesis of the designed...

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Autori principali: A.S.V.L. Sruthi, Syed Faizan, Hemant Vikram, N.G. Veena, Aishwarya Susil, Haritha Harindranath, S. Vasanth Kumar, Vasanth Kumar Shivaraju, B.R. Prashantha Kumar
Natura: Artigo
Lingua:Inglês
Pubblicazione: Elsevier 2024-01-01
Serie:Results in Chemistry
Soggetti:
Hantzsch 1,4-dihydropyridines
Anticancer activity
EGFR
HER-2
MCF-7
Docking
Accesso online:http://www.sciencedirect.com/science/article/pii/S2211715624001097
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