Glucose controls co-translation of structurally related mRNAs via the mTOR and eIF2 pathways in human pancreatic beta cells

Pancreatic beta cell response to glucose is critical for the maintenance of normoglycemia. A strong transcriptional response was classically described in rodent models but, interestingly, not in human cells. In this study, we exposed human pancreatic beta cells to an increased concentration of gluco...

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Autori principali:	Manuel Bulfoni, Costas Bouyioukos, Albatoul Zakaria, Fabienne Nigon, Roberta Rapone, Laurence Del Maestro, Slimane Ait-Si-Ali, Raphaël Scharfmann, Bertrand Cosson
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Frontiers Media S.A. 2022-08-01
Serie:	Frontiers in Endocrinology
Soggetti:	response to glucose mRNA feature translation regulation Human beta cells RNA co-regulation mTOR
Accesso online:	https://www.frontiersin.org/articles/10.3389/fendo.2022.949097/full
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