Neuronal expression of β2M and MHC I are essential for peripheral surveillance and targeting of neuron-restricted antigens

Neurons upregulate major histocompatibility complex class I (MHC I) during demyelination, enabling the presentation of self-antigens to cytotoxic CD8+ T cells. While this phenomenon is well described in multiple sclerosis lesions, its functional significance for disease progression remains poorly un...

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Hlavní autoři:	Benjamin D. S. Clarkson, Melanie E. Schille, Ivy J. Z. Garland, Maria Westphal, Charles L. Howe
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Frontiers Media S.A. 2026-06-01
Edice:	Frontiers in Neurology
Témata:	β2M knockout CD8+ T cell cuprizone EAE MHC I multiple sclerosis
On-line přístup:	https://www.frontiersin.org/articles/10.3389/fneur.2026.1813496/full
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