Neuronal expression of β2M and MHC I are essential for peripheral surveillance and targeting of neuron-restricted antigens
Neurons upregulate major histocompatibility complex class I (MHC I) during demyelination, enabling the presentation of self-antigens to cytotoxic CD8+ T cells. While this phenomenon is well described in multiple sclerosis lesions, its functional significance for disease progression remains poorly un...
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| Główni autorzy: | , , , , |
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| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
Frontiers Media S.A.
2026-06-01
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| Seria: | Frontiers in Neurology |
| Hasła przedmiotowe: | |
| Dostęp online: | https://www.frontiersin.org/articles/10.3389/fneur.2026.1813496/full |
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