ECM29/proteasome-mediated self-antigen generation by CNS-resident neuroglia promotes regulatory T cell activation

Summary: Proteasomes generate antigenic peptides presented on cell surfaces—a process that, in neuroglia, is highly responsive to external stimuli. However, the function of the self-antigens presented by CNS parenchymal cells remains unclear. Here, we report that the fidelity of neuroglial self-anti...

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Autori principali:	Sheng-Wen Chen, Ying Chu, Chien-Hsin Chu, Xuan-Dieu Thi Pham, Hang Pong Ng, Chin-Lin Guo, Pei-Lin Cheng
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Elsevier 2025-01-01
Serie:	Cell Reports
Soggetti:	CP: Neuroscience CP: Immunology
Accesso online:	http://www.sciencedirect.com/science/article/pii/S2211124724015122
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