A bitopic agonist bound to the dopamine 3 receptor reveals a selectivity site
Abstract Although aminergic GPCRs are the target for ~25% of approved drugs, developing subtype selective drugs is a major challenge due to the high sequence conservation at their orthosteric binding site. Bitopic ligands are covalently joined orthosteric and allosteric pharmacophores with the poten...
Zapisane w:
| Główni autorzy: | , , , , , , , , |
|---|---|
| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
Nature Portfolio
2024-09-01
|
| Seria: | Nature Communications |
| Dostęp online: | https://doi.org/10.1038/s41467-024-51993-4 |
| Etykiety: |
Nie ma etykietki, Dołącz pierwszą etykiete!
|