A bitopic agonist bound to the dopamine 3 receptor reveals a selectivity site
Abstract Although aminergic GPCRs are the target for ~25% of approved drugs, developing subtype selective drugs is a major challenge due to the high sequence conservation at their orthosteric binding site. Bitopic ligands are covalently joined orthosteric and allosteric pharmacophores with the poten...
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| Autori principali: | , , , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Nature Portfolio
2024-09-01
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| Serie: | Nature Communications |
| Accesso online: | https://doi.org/10.1038/s41467-024-51993-4 |
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