A bitopic agonist bound to the dopamine 3 receptor reveals a selectivity site

Abstract Although aminergic GPCRs are the target for ~25% of approved drugs, developing subtype selective drugs is a major challenge due to the high sequence conservation at their orthosteric binding site. Bitopic ligands are covalently joined orthosteric and allosteric pharmacophores with the poten...

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Bibliografiske detaljer

Principais autores:	Sandra Arroyo-Urea, Antonina L. Nazarova, Ángela Carrión-Antolí, Alessandro Bonifazi, Francisco O. Battiti, Jordy Homing Lam, Amy Hauck Newman, Vsevolod Katritch, Javier García-Nafría
Format:	Artigo
Sprog:	Inglês
Udgivet:	Nature Portfolio 2024-09-01
Serier:	Nature Communications
Online adgang:	https://doi.org/10.1038/s41467-024-51993-4
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