Amyloidogenic regions in beta-strands II and III modulate the aggregation and toxicity of SOD1 in living cells
Mutations in the protein superoxide dismutase-1 (SOD1) promote its misfolding and aggregation, ultimately causing familial forms of the debilitating neurodegenerative disease amyotrophic lateral sclerosis (ALS). Currently, over 220 (mostly missense) ALS-causing mutations in the SOD1 protein have bee...
Збережено в:
| Автори: | , , , , , |
|---|---|
| Формат: | Artigo |
| Мова: | Inglês |
| Опубліковано: |
The Royal Society
2024-06-01
|
| Серія: | Open Biology |
| Предмети: | |
| Онлайн доступ: | https://royalsocietypublishing.org/doi/10.1098/rsob.230418 |
| Теги: |
Немає тегів, Будьте першим, хто поставить тег для цього запису!
|