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Amyloidogenic regions in beta-strands II and III modulate the aggregation and toxicity of SOD1 in living cells

Mutations in the protein superoxide dismutase-1 (SOD1) promote its misfolding and aggregation, ultimately causing familial forms of the debilitating neurodegenerative disease amyotrophic lateral sclerosis (ALS). Currently, over 220 (mostly missense) ALS-causing mutations in the SOD1 protein have bee...

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Principais autores: Luke McAlary, Jeremy R. Nan, Clay Shyu, Mine Sher, Steven S. Plotkin, Neil R. Cashman
Formato: Artigo
Idioma:Inglês
Publicado em: The Royal Society 2024-06-01
coleção:Open Biology
Assuntos:
protein aggregation
protein homeostasis
amyotrophic lateral sclerosis
amyloid
SOD1
Acesso em linha:https://royalsocietypublishing.org/doi/10.1098/rsob.230418
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