Malformin C preferentially kills glioblastoma stem‐like cells via concerted induction of proteotoxic stress and autophagic flux blockade

Glioblastoma is a highly aggressive brain tumor for which there is no cure. The dire prognosis of this disease is largely attributable to a high level of heterogeneity, including the presence of a subpopulation of tumor‐initiating glioblastoma stem‐like cells (GSCs), which are refractory to chemo‐ a...

ver descrição completa

Detalhes bibliográficos

Principais autores:	Emma Phillips, Sizèd vanEnk, Sara Kildgaard, Silja Schlue, Mona Göttmann, Victoria Jennings, Frederic Bethke, Gabriele Müller, Christel Herold‐Mende, Daniel Pastor‐Flores, Martin Schneider, Dominic Helm, Thomas Ostenfeld Larsen, Violaine Goidts
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Wiley 2025-03-01
coleção:	Molecular Oncology
Assuntos:	autophagy cancer compound screen glioblastoma proteostasis stem cells
Acesso em linha:	https://doi.org/10.1002/1878-0261.13756
Tags:	Adicionar Tag Sem tags, seja o primeiro a adicionar uma tag!