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Defective transcription elongation in human cancers imposes targetable proteotoxic vulnerability

Successful cancer therapy is contingent on identifying cancer-specific aberrant phenotypes and their associated vulnerabilities. We recently reported that a subset of almost every cancer type contains a genome-wide defect in RNA Polymerase II-mediated transcription elongation (TEdef), which impairs...

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Principais autores: B. Muhammad, L.G. Parks, K. Komurov, L.M. Privette Vinnedge
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2022-02-01
Serier:Translational Oncology
Fag:
Transcription elongation defects (TEdef)
Aggresomes
Protein homeostasis
Proteotoxic stress
Autophagy
Online adgang:http://www.sciencedirect.com/science/article/pii/S1936523321003144
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