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SAM68 directs STING signaling to apoptosis in macrophages

Abstract DNA is a danger signal sensed by cGAS to engage signaling through STING to activate innate immune functions. The best-studied downstream responses to STING activation include expression of type I interferon and inflammatory genes, but STING also activates other pathways, including apoptosis...

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Autori principali: Demi van der Horst, Naziia Kurmasheva, Mikkel H. S. Marqvorsen, Sonia Assil, Anna H. F. Rahimic, Christoph F. Kollmann, Leandro Silva da Costa, Qi Wu, Jian Zhao, Eleonora Cesari, Marie B. Iversen, Fanghui Ren, Trine I. Jensen, Ryo Narita, Vivien R. Schack, Bao-cun Zhang, Rasmus O. Bak, Claudio Sette, Robert A. Fenton, Jacob G. Mikkelsen, Søren R. Paludan, David Olagnier
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Portfolio 2024-03-01
Serie:Communications Biology
Accesso online:https://doi.org/10.1038/s42003-024-05969-1
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