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Variability in detection and quantification of interferon β-1b–induced neutralizing antibodies

<p>Abstract</p> <p>Background</p> <p>Interferon-beta (IFNB) therapy for multiple sclerosis can lead to the induction of neutralizing antibodies (NAbs) against IFNB. Various methods are used for detection and quantification of NAbs.</p> <p>Methods</p> <p>Blood samples from 125 IFNB-1b–treated patient...

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Autori principali: Hartung Hans-Peter, Kieseier Bernd, Goodin Douglas S, Arnason Barry GW, Comi Giancarlo, Cook Stuart, Filippi Massimo, Jeffery Douglas R, Kappos Ludwig, Bogumil Timon, Stemper Brigitte, Sandbrink Rupert, Nakada Yukiko, Nakajima Haruhiko, Schwenke Susanne, Lehr Stephan, Heubach Jürgen, Pohl Christoph, Reischl Joachim
Natura: Artigo
Lingua:Inglês
Pubblicazione: BMC 2012-06-01
Serie:Journal of Neuroinflammation
Soggetti:
Multiple sclerosis
Clinical trials randomized controlled
IFNB-1b
Interferon beta
Neutralizing antibodies
Round robin
Accesso online:http://www.jneuroinflammation.com/content/9/1/129
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