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Variability in detection and quantification of interferon β-1b–induced neutralizing antibodies

<p>Abstract</p> <p>Background</p> <p>Interferon-beta (IFNB) therapy for multiple sclerosis can lead to the induction of neutralizing antibodies (NAbs) against IFNB. Various methods are used for detection and quantification of NAbs.</p> <p>Methods</p> <p>Blood samples from 125 IFNB-1b–treated patient...

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Hlavní autoři: Hartung Hans-Peter, Kieseier Bernd, Goodin Douglas S, Arnason Barry GW, Comi Giancarlo, Cook Stuart, Filippi Massimo, Jeffery Douglas R, Kappos Ludwig, Bogumil Timon, Stemper Brigitte, Sandbrink Rupert, Nakada Yukiko, Nakajima Haruhiko, Schwenke Susanne, Lehr Stephan, Heubach Jürgen, Pohl Christoph, Reischl Joachim
Médium: Artigo
Jazyk:Inglês
Vydáno: BMC 2012-06-01
Edice:Journal of Neuroinflammation
Témata:
Multiple sclerosis
Clinical trials randomized controlled
IFNB-1b
Interferon beta
Neutralizing antibodies
Round robin
On-line přístup:http://www.jneuroinflammation.com/content/9/1/129
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