Thioredoxin‐80 is a product of alpha‐secretase cleavage that inhibits amyloid‐beta aggregation and is decreased in Alzheimer's disease brain

Abstract Thioredoxin‐1 (Trx1) is an endogenous dithiol reductant and antioxidant that was shown to be decreased in Alzheimer's disease (AD) neurons. A truncated form of Trx1, thioredoxin 80 (Trx80), was reported to be secreted from monocytes having cytokine activity. Here, we show that Trx80 is pres...

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Egile Nagusiak:	Francisco Gil‐Bea, Susanne Akterin, Torbjörn Persson, Laura Mateos, Anna Sandebring, Javier Avila‐Cariño, Angel Gutierrez‐Rodriguez, Erik Sundström, Arne Holmgren, Bengt Winblad, Angel Cedazo‐Minguez
Formatua:	Artigo
Hizkuntza:	Inglês
Argitaratua:	Springer Nature 2012-08-01
Saila:	EMBO Molecular Medicine
Gaiak:	ADAM Alzheimer's disease amyloid‐β α‐secretase thioredoxin
Sarrera elektronikoa:	https://doi.org/10.1002/emmm.201201462
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