Thioredoxin‐80 is a product of alpha‐secretase cleavage that inhibits amyloid‐beta aggregation and is decreased in Alzheimer's disease brain

Abstract Thioredoxin‐1 (Trx1) is an endogenous dithiol reductant and antioxidant that was shown to be decreased in Alzheimer's disease (AD) neurons. A truncated form of Trx1, thioredoxin 80 (Trx80), was reported to be secreted from monocytes having cytokine activity. Here, we show that Trx80 is pres...

Descripció completa

Dades bibliogràfiques

Autors principals:	Francisco Gil‐Bea, Susanne Akterin, Torbjörn Persson, Laura Mateos, Anna Sandebring, Javier Avila‐Cariño, Angel Gutierrez‐Rodriguez, Erik Sundström, Arne Holmgren, Bengt Winblad, Angel Cedazo‐Minguez
Format:	Artigo
Idioma:	Inglês
Publicat:	Springer Nature 2012-08-01
Col·lecció:	EMBO Molecular Medicine
Matèries:	ADAM Alzheimer's disease amyloid‐β α‐secretase thioredoxin
Accés en línia:	https://doi.org/10.1002/emmm.201201462
Etiquetes:	Afegir etiqueta Sense etiquetes, Sigues el primer a etiquetar aquest registre!