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Changes in the sensitivity of GABAA current rundown to drug treatments in a model of temporal lobe epilepsy

The pharmacological treatment of mesial temporal lobe epilepsy (mTLE), the most common epileptic syndrome in adults, is still unsatisfactory, as one third of the patients are or become refractory to antiepileptic agents. Refractoriness may depend upon drug-induced alterations, but the disease per se...

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Hoofdauteurs: Pierangelo eCifelli, Eleonora ePalma, Cristina eRoseti, Gianluca eVerlengia, Michele eSimonato
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Frontiers Media S.A. 2013-07-01
Reeks:Frontiers in Cellular Neuroscience
Onderwerpen:
Hippocampus
Neocortex
Pilocarpine
BDNF
GABA
levetiracetam
Online toegang:http://journal.frontiersin.org/Journal/10.3389/fncel.2013.00108/full
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