Glycyrrhizin ameliorates colorectal cancer progression by regulating NHEJ pathway through inhibiting HMGB1-induced DNA damage response

Abstract As one of the most common malignancies, colorectal cancer (CRC) usually starts with a benign lesion and accumulates DNA damage as it progresses to full-fledged cancer. Glycyrrhizin (GL) has been found to alleviate tumor growth and inflammation, while the role of GL influences DNA damage res...

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Autori principali:	Yuhui Han, Wenjiong Sheng, Xiuxin Liu, Haide Liu, Xinyu Jia, Honghui Li, Changyuan Wang, Bin Wang, Tao Hu, Yanchao Ma
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Nature Portfolio 2024-10-01
Serie:	Scientific Reports
Soggetti:	Colorectal cancer (CRC) Glycyrrhizin (GL) HMGB1 DNA damage response (DDR) NHEJ
Accesso online:	https://doi.org/10.1038/s41598-024-76155-w
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