PAXX Is an Accessory c-NHEJ Factor that Associates with Ku70 and Has Overlapping Functions with XLF

In mammalian cells, classical non-homologous end joining (c-NHEJ) is critical for DNA double-strand break repair induced by ionizing radiation and during V(D)J recombination in developing B and T lymphocytes. Recently, PAXX was identified as a c-NHEJ core component. We report here that PAXX-deficien...

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Autors principals:	Satish K. Tadi, Carine Tellier-Lebègue, Clément Nemoz, Pascal Drevet, Stéphane Audebert, Sunetra Roy, Katheryn Meek, Jean-Baptiste Charbonnier, Mauro Modesti
Format:	Artigo
Idioma:	Inglês
Publicat:	Elsevier 2016-10-01
Col·lecció:	Cell Reports
Matèries:	DNA double-strand break repair NHEJ V(D)J recombination MMEJ PAXX XLF XRCC4 Ku Ku70 DNA ligase 4
Accés en línia:	http://www.sciencedirect.com/science/article/pii/S2211124716312487
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