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Cytoplasmic HMGB1 promotes and interacts with BECN1 through ZNF460 to induce autophagy and accelerate radioresistance in colorectal cancer cells

Radioresistance results in relapse and treatment failure in locally advanced colorectal cancer (CRC) patients. HMGB1 is reportedly associated with radioresistance in esophageal squamous cell carcinoma and breast cancer. However, its role in the response of CRC to radiotherapy has not been fully eluc...

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Principais autores: Yuhui Han, Xiuxin Liu, Wenjiong Sheng, Ruixue Kuang, Yan Zhang, Xinyu Jia, A. M. Abd El-Aty, Tao Hu, Bin Wang, Yanchao Ma
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2025-10-01
Serier:Frontiers in Immunology
Fag:
colorectal cancer
radioresistance
HMGB1
BECN1
autophagy
ZNF460
Online adgang:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1642915/full
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