Sec17 (α-SNAP) and an SM-tethering complex regulate the outcome of SNARE zippering in vitro and in vivo

Zippering of SNARE complexes spanning docked membranes is essential for most intracellular fusion events. Here, we explore how SNARE regulators operate on discrete zippering states. The formation of a metastable trans-complex, catalyzed by HOPS and its SM subunit Vps33, is followed by subsequent zip...

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Principais autores:	Matthew L Schwartz, Daniel P Nickerson, Braden T Lobingier, Rachael L Plemel, Mengtong Duan, Cortney G Angers, Michael Zick, Alexey J Merz
Format:	Artigo
Jezik:	Inglês
Izdano:	eLife Sciences Publications Ltd 2017-09-01
Serija:	eLife
Teme:	Sec1/Munc18 Vps33 HOPS Rab AP-3 lysosome
Online dostop:	https://elifesciences.org/articles/27396
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