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DGAT1 protects tumor from lipotoxicity, emerging as a promising metabolic target for cancer therapy

We recently demonstrated that glioblastoma, the most lethal brain cancer, upregulates diacylglycerol O-acyltransferase 1 (DGAT1) to store excess fatty acids into triglycerides to prevent lipotoxicity and promote tumor growth. Targeting DGAT1 resulted in marked tumor cell death by triggering extensiv...

Бүрэн тодорхойлолт

-д хадгалсан:
Номзүйн дэлгэрэнгүй
Үндсэн зохиолчид: Xiang Cheng, Feng Geng, Deliang Guo
Формат: Artigo
Хэл сонгох:Inglês
Хэвлэсэн: Taylor & Francis Group 2020-11-01
Цуврал:Molecular & Cellular Oncology
Нөхцлүүд:
Онлайн хандалт:http://dx.doi.org/10.1080/23723556.2020.1805257
Шошгууд: Шошго нэмэх
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