DGAT1 protects tumor from lipotoxicity, emerging as a promising metabolic target for cancer therapy
We recently demonstrated that glioblastoma, the most lethal brain cancer, upregulates diacylglycerol O-acyltransferase 1 (DGAT1) to store excess fatty acids into triglycerides to prevent lipotoxicity and promote tumor growth. Targeting DGAT1 resulted in marked tumor cell death by triggering extensiv...
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| Glavni autori: | , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Taylor & Francis Group
2020-11-01
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| Serija: | Molecular & Cellular Oncology |
| Teme: | |
| Online pristup: | http://dx.doi.org/10.1080/23723556.2020.1805257 |
| Oznake: |
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