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Site-Specific Tryptophan Labels Reveal Local Microsecond–Millisecond Motions of Dihydrofolate Reductase

Many enzymes are known to change conformations during their catalytic cycle, but the role of these protein motions is not well understood. <i>Escherichia coli</i> dihydrofolate reductase (DHFR) is a small, flexible enzyme that is often used as a model system for understanding enzyme dynamics. Recent...

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Principais autores: Morgan B. Vaughn, Chloe Biren, Qun Li, Ashwin Ragupathi, R. Brian Dyer
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI AG 2020-08-01
coleção:Molecules
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Acesso em linha:https://www.mdpi.com/1420-3049/25/17/3819
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