Transgenesis of mammalian PABP reveals mRNA polyadenylation as a general stress response mechanism in bacteria
Summary: In eukaryotes, mRNA 3′-polyadenylation triggers poly(A) binding protein (PABP) recruitment and stabilization. In a stark contrast, polyadenylation marks mRNAs for degradation in bacteria. To study this difference, we trans-express the mammalian nuclear PABPN1 chromosomally and extra-chromos...
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| Principais autores: | , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Elsevier
2021-10-01
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| Serier: | iScience |
| Fag: | |
| Online adgang: | http://www.sciencedirect.com/science/article/pii/S2589004221010877 |
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