AI-Based Drug Discovery of TKIs Targeting L858R/T790M/C797S-Mutant EGFR in Non-small Cell Lung Cancer

Lung cancer has a high mortality rate, and non-small cell lung cancer (NSCLC) is the most common type of lung cancer. Patients have been observed to acquire resistance against various anticancer agents used for NSCLC due to L858R (or Exon del19)/T790M/C797S-EGFR mutations. Therefore, next-generation...

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Autores principales:	Geunho Choi, Daegeun Kim, Junehwan Oh
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Frontiers Media S.A. 2021-07-01
Colección:	Frontiers in Pharmacology
Materias:	NSCLC EGFR tyrosine kinase inhibitors (TKIs) transfer learning LSTM virtual screening
Acceso en línea:	https://www.frontiersin.org/articles/10.3389/fphar.2021.660313/full
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