Quinoxalinones as A Novel Inhibitor Scaffold for EGFR (L858R/T790M/C797S) Tyrosine Kinase: Molecular Docking, Biological Evaluations, and Computational Insights

Combating acquired drug resistance of EGFR tyrosine kinase (TK) is a great challenge and an urgent necessity in the management of non-small cell lung cancers. The advanced EGFR (L858R/T790M/C797S) triple mutation has been recently reported, and there have been no specific drugs approved for this str...

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Principais autores:	Utid Suriya, Panupong Mahalapbutr, Watchara Wimonsong, Sirilata Yotphan, Kiattawee Choowongkomon, Thanyada Rungrotmongkol
Formato:	Artigo
Idioma:	Inglês
Publicado:	MDPI AG 2022-12-01
Series:	Molecules
Assuntos:	EGFR tyrosine kinase EGFR (L858R/T790M/C797S) TK lung cancer non-small cell lung cancer in silico drug discovery and development
Acceso en liña:	https://www.mdpi.com/1420-3049/27/24/8901
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