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Fused in silico and bioactivity evaluation method for drug discovery: T001-10027877 was identified as an antiproliferative agent that targets EGFRT790M/C797S/L858R and EGFRT790M/L858R

Abstract Background Facing the significant challenge of overcoming drug resistance in cancer treatment, particularly resistance caused by mutations in epidermal growth factor receptor (EGFR), the aim of our study was to identify potent EGFR inhibitors effective against the T790M/C797S/L858R mutant,...

Whakaahuatanga katoa

I tiakina i:
Ngā kaituhi matua: Linxiao Wang, Xiaoling Huang, Shidi Xu, Yufeng An, Xinya Lv, Wufu Zhu, Shan Xu, Yuanbiao Tu, Shuhui Chen, Qiaoli Lv, Pengwu Zheng
Hōputu: Artigo
Reo:Inglês
I whakaputaina: BMC 2024-08-01
Rangatū:BMC Chemistry
Ngā marau:
EGFRT790M/C797S/L858R and EGFRT790M/L858R
Machine learning
Virtual screening
Bioactivity evaluation
Antiproliferative agent
Urunga tuihono:https://doi.org/10.1186/s13065-024-01279-z
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