Batch variability and anti-inflammatory effects of iPSC-derived mesenchymal stromal cell extracellular vesicles in osteoarthritis in vitro model

Mesenchymal stromal cell-derived extracellular vesicles (MSC-EVs) hold promise as a cell-free therapy for osteoarthritis (OA), due to their immunomodulatory and anti-inflammatory properties. However, the need for large-scale expansion to obtain MSC-EVs for clinical use can lead to senescence-related...

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Autori principali:	Maria Elisabetta Federica Palamà, Cansu Gorgun, Matteo Rovere, Georgina M. Shaw, Daniele Reverberi, Matteo Formica, Emanuele Quarto, Frank Barry, Mary Murphy, Chiara Gentili
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Frontiers Media S.A. 2025-04-01
Serie:	Frontiers in Bioengineering and Biotechnology
Soggetti:	extracellular vesicle (EV) mesenchymal stromal cells induced pluripotent derived mesenchymal stromal cells osteoarthritis inflammation
Accesso online:	https://www.frontiersin.org/articles/10.3389/fbioe.2025.1536843/full
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