Six-helix bundle completion in the distal C-terminal heptad repeat region of gp41 is required for efficient human immunodeficiency virus type 1 infection

Abstract Background The native pre-fusion structure of gp120/gp41 complex of human immunodeficiency virus type 1 was recently revealed. In the model, the helices of gp41 (α6, α7, α8, and α9) form a four-helix collar underneath trimeric gp120. Gp41 is a class I fusion protein and mediates membrane fu...

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Bibliografische gegevens

Hoofdauteurs:	Dehua Liu, Hongyun Wang, Mizuki Yamamoto, Jiping Song, Rui Zhang, Qingling Du, Yasushi Kawaguchi, Jun-ichiro Inoue, Zene Matsuda
Formaat:	Artigo
Taal:	Inglês
Gepubliceerd in:	BMC 2018-04-01
Reeks:	Retrovirology
Onderwerpen:	Human immunodeficiency virus type 1 Envelope protein Membrane fusion Fusion pore Heptad repeat Six-helix bundle
Online toegang:	http://link.springer.com/article/10.1186/s12977-018-0410-9
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