A Traceless Selection: Counter-selection System That Allows Efficient Generation of Transposon and CRISPR-modified T-cell Products

Recent years have seen major breakthroughs in genome-engineering systems, such as transposon-mediated gene delivery systems and CRISPR-Cas9-mediated genome-editing tools. In these systems, transient expression of auxiliary genes is responsible for permanent genomic modification. For both systems, it...

Ausführliche Beschreibung

Bibliografische Detailangaben

Hauptverfasser:	Riccardo Mezzadra, Andreas Hollenstein, Raquel Gomez-Eerland, Ton N Schumacher
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Elsevier 2016-01-01
Schriftenreihe:	Molecular Therapy: Nucleic Acids
Schlagworte:	deletion gene insertion modification
Online-Zugang:	http://www.sciencedirect.com/science/article/pii/S2162253117300264
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