Structures of C-mannosylated anti-adhesives bound to the type 1 fimbrial FimH adhesin

Selective inhibitors of the type 1 fimbrial adhesin FimH are recognized as attractive alternatives for antibiotic therapies and prophylaxes against Escherichia coli infections such as urinary-tract infections. To construct these inhibitors, the α-d-mannopyranoside of high-mannose N-glycans, recogniz...

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Λεπτομέρειες βιβλιογραφικής εγγραφής

Κύριοι συγγραφείς:	Jerome de Ruyck, Marc F. Lensink, Julie Bouckaert
Μορφή:	Artigo
Γλώσσα:	Inglês
Έκδοση:	International Union of Crystallography 2016-05-01
Σειρά:	IUCrJ
Θέματα:	bacterial adhesion anti-adhesives C-mannosides FimH variable immunoglobulin fold protein structure X-ray crystallography intermolecular interactions hydrogen bonding
Διαθέσιμο Online:	http://scripts.iucr.org/cgi-bin/paper?S2052252516002487
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