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Diazirine-functionalized mannosides for photoaffinity labeling: trouble with FimH

Photoaffinity labeling is frequently employed for the investigation of ligand–receptor interactions in solution. We have employed an interdisciplinary methodology to achieve facile photolabeling of the lectin FimH, which is a bacterial protein, crucial for adhesion, colonization and infection. Follo...

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Autori principali: Femke Beiroth, Tomas Koudelka, Thorsten Overath, Stefan D. Knight, Andreas Tholey, Thisbe K. Lindhorst
Natura: Artigo
Lingua:Inglês
Pubblicazione: Beilstein-Institut 2018-07-01
Serie:Beilstein Journal of Organic Chemistry
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Accesso online:https://doi.org/10.3762/bjoc.14.163
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