Deregulated expression of A1, Bcl-2, Bcl-xL, and Mcl-1 antiapoptotic proteins and Bid, Bad, and Bax proapoptotic genes in polycythemia vera patients

Apoptosis deregulation might have a role in the pathophysiology of polycythemia vera (PV). This study evaluated Bcl-2 molecule expression in CD34+ cells and leukocytes in 12 PV patients. Gene expression was investigated by real time PCR using SybrGreen Quantitect kit and protein expression was evalu...

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Główni autorzy:	Elainy Patricia Lino Gasparotto, Raquel Tognon, Aline Fernanda Ferreira, Gislane Lelis Vilela Oliveira, Patrícia Vianna Bonini Palma, Maria Aparecida Zanichelli, Elizabeth Xisto Souto, Carlos Eduardo Engel Velano, Belinda Pinto Simões, Rita de Cassia Viu Carrara, Simone Kashima, Dimas Tadeu Covas, Fabíola Attie de Castro, Ana Maria de Souza
Format:	Artigo
Język:	Inglês
Wydane:	Universidade de São Paulo, Faculdade de Ciências Farmacêuticas 2011-12-01
Seria:	Brazilian Journal of Pharmaceutical Sciences
Hasła przedmiotowe:	Policitemia vera Mutação gênica Expressão gênica Apoptose Membros da Família Bcl-2 Polycythemia vera Gene mutation Gene expression Apoptosis Bcl-2 family members
Dostęp online:	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502011000400025
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