Vincristine-induced brain toxicity is reduced with prevention of peripheral axon degeneration in Sarm1 knockout mice

Abstract Vincristine is an essential chemotherapy agent administered for various pediatric cancers including acute lymphoblastic leukemia (ALL). While multi-agent chemotherapy for pediatric ALL is highly curative, with survival approaching 95%, it carries the risk of irreversible neurocognitive late...

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Principais autores:	Jonas Yeung, Prisca Hsu, Jordan Mak, Ali Darbandi, Anne L. Wheeler, Rosanna Weksberg, Sharon L. Guger, Russell J. Schachar, Shinya Ito, Johann Hitzler, Brian J. Nieman
פורמט:	Artigo
שפה:	Inglês
יצא לאור:	BMC 2025-12-01
סדרה:	Acta Neuropathologica Communications
נושאים:	SARM1 Axon degeneration Vincristine Peripheral neuropathy Chemotherapy MRI
גישה מקוונת:	https://doi.org/10.1186/s40478-025-02171-0
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